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F. Nikhat ¹, D. Satyanarayana ¹, M. G. Purohit ¹, M. A. Hadi ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga-585201, IN

Abstract

The main objective of the present investigation is to evaluate the analgesic activity of formulate topical gel containing ScReX-2b 2%, Carbopol 940 1.0%, Triethanol amine 0.50%, Propylene glycol 10%, Methanol 2.5% Water 100ml and evaluated for the same.

Keywords

Analgesic, Topical, Gel, Evaluated.

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F. Nikhat ¹, D. Satyanarayana ², D. K. Suresh ², M. G. Purohit ², H. Raza ², S. M. Hamza ²

Affiliations
1 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga-585201, IN
2 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga-585201, IN

Abstract

The present study was carried out to investigate the analgesic activity of the prepared formulation 50mg/kg and 200mg/kg body weight in the form of gel on albino rats by Tail immersion method. The different dose level of prepared gel was applied to the rat according to the body weight to the tail which is marked at 5cm and was subjected to analgesic activity. The significance analgesic activity is observed after 1_/2 hr of the application which was compared with standard dichlofenac gel, the activity decreased after 2 hr of the application. The gel was prepared from the isolated constituents of syzygium cuminii (L) skeel ischolar_main extract. The aim of the work is to prepare such a formulation which is having natural analgesic activity. The expected result from the formulation was obtained for first time. The further work is going on in our laboratory.

Keywords

Analgesic, Dichlofenac Gel, Formulation, Constituents.

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F. Nikhat ¹, D. Satyanarayana ¹, M. G. Purohit ¹, Bharat ¹, A. Moid ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga-585201, IN

Abstract

Syzygium cuminii (L) skeel commonly known as 'jamun' is widely used in Indian folk medicine for the treatment of diabetes Mellitus. The present study an attempt has been made to produce a complete analytical and chemical profile of the isolated constituents of ischolar_main's of syzygium cuminii(L) skeel . The pharmacological and pharmaceutical work is going on in our laboratory.

Keywords

Syzygium cuminii (L) skeel, Constituents, Diabetes.

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A. Moid ¹, F. Nikhat ¹, M. G. Purohit ¹, A. Thouheed ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga - 585102, IN

Abstract

The prevalence of isoxazole cores in natural and biologically active molecules has stimulated the need for elegant and efficient ways to make these heterocycles as lead. A systematic investigation of this class of heterocycle revealed that isoxazole containing pharmacoactive agent's possess analgesic, anti-inflammatory and antimicrobial activities. 4-(5'- substituted-aryl-4,5'-dihydro-isoxazole-3'-yl-amino) phenols possessing potent biological activities. N-(4'- hydroxyphenyl) acetamide (2) was synthesized by the condensation of p-amino phenol (1) with acetyl chloride by refluxing in alkaline medium for 20 minutes. 3-substituted N-(4'-hydroxyphenyl) propanamides (3a-g) were prepared by the reaction of N-(4-hydroxy phenyl) acetamide with various substituted aryl aldehydes by refluxing for 6 hours in ethanol. The resultant compounds on refluxing for 6 hours with hydroxylamine hydrochloride gave the title compounds 4-(5'-substituted-aryl-4', 5'-dihydro-isoxazole-3'-yl-amino) phenols (4a-g). The synthesized derivatives have been characterized by FT-IR, 1HNMR and Mass spectral analysis. All the derivatives synthesized were screened for their anti-bacterial and antifungal activities at the concentration level of 100 μg/ml by cup-plate method. Some of the compounds such as 4a, 4b, 4c, 4d and 4f have shown significant antibacterial and antifungal activity when compared to standard drugs Ciprofloxacin (antibacterial activity) and Clotrimazole (antifungal activity). The results obtained indicate that, when the phenyl group at 5^th position of isoxazole nucleus contains the substituents as electron withdrawing atoms/groups particularly at ortho and meta positions could be a decisive factor for the compounds to have the increased potency over the other positions.

Keywords

Isoxazoles Derivatives, Anti-Bacterial Activity, Anti-Fungal Activity.

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